Start On I-440 E: From Downtown Raleigh, Take I-440 E Toward Us-64 E/Us-264 E.Merge Onto Us-264 E: Continue On Us-264 E Toward Zebulon And Middlesex. Take Exit 436 For Nc-231 S: Exit Toward Middlesex/Nc-231 S. Merge Onto Nc-231 S: Follow Nc-231 S Into The Town Of Middlesex. Turn Right Onto W Pamlico St: After Entering Middlesex, Turn Right Onto W Pamlico St. Arrive At Destination: 12449 W Pamlico St Will Be On Your Right.